The role of inducible nitric oxide synthase in cardiac allograft rejection.

نویسندگان

  • P Cannon
  • X Yang
  • M J Szabolcs
  • S Ravalli
  • R R Sciacca
  • R E Michler
چکیده

Paul J. Cannon , Xiaochun Yang , Matthias J. Szabolcs , Stefano Ravalli , Robert R. Sciacca , Robert E. Michler b a Department of Medicine, Columbia UniÕersity College of Physicians and Surgeons, New York, NY, USA b Department of Surgery, Columbia UniÕersity College of Physicians and Surgeons, New York, NY, USA c Department of Pathology, Columbia UniÕersity College of Physicians and Surgeons, New York, NY, USA

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منابع مشابه

Time course and cellular localization of inducible nitric oxide synthases expression during cardiac allograft rejection.

BACKGROUND We have demonstrated that inhibition of inducible nitric oxide synthase (NOS) ameliorated acute cardiac allograft rejection. This study determined the time course and cellular localization of inducible NOS expression during the histologic progression of unmodified acute rat cardiac allograft rejection. METHODS Tissue from syngeneic (ACI to ACI) and allogeneic (Lewis to ACI) transpl...

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EXPRESSION OF INDUCIBLE NITRIC OXIDE SYNTHASE GENE (iNOS) STIMULATED BY HYDROGEN PEROXIDE IN HUMAN ENDOTHELIAL CELLS

Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...

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Comparison of inducible nitric oxide synthase activity in pancreatic islets of young and aged rats

Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...

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Indirect evidence suggests that estrogen is involved in the etiology of breast cancer. Estrogen is also thought to modulate nitric oxide (NO) in human breast tumor tissue via regulation of inducible nitric oxide synthase (iNOS). Objectives of this study were to determine whether estradiol (E2) affects iNOS expression level in breast cancer cells and to study the effect of various concentrations...

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عنوان ژورنال:
  • Cardiovascular research

دوره 38 1  شماره 

صفحات  -

تاریخ انتشار 1998